Kikuchi ME-NBI (SNADET)
ME-NBI algorithm (Kikuchi 2014) for SNADET. Monotype vs mixed surface, then vascular pattern (network / ISV / absent / unclassified) to estimate Vienna C3 vs C4/5. ME-CV is Toya 2020.
Classification overview
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Mixed type · Multiple surface patterns
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Monotype · Single surface pattern
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Unclassified vessels · Unclassified vascular pattern
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ISV · Intrastructural vascular pattern
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Network · Network vascular pattern
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Absent vessels · Absent vascular pattern
Algorithm
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Algorithm
Is the surface pattern single or multiple?
ME-NBI. Single = monotype. Multiple = mixed / multiplicity.
Multiple (mixed)
Single (monotype)
Diagnosis
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Mixed type
Multiple surface patterns
Definition
Lesions displaying multiple surface patterns (multiplicity)
Vienna
Category 4/5 (100% in Kikuchi 2014 series)
Note: Multiple surface patterns → C4/5.
Definition
Lesions displaying a single surface pattern
Surface detail
Preserved, micrified, or absent mucosal structure (see vascular pattern next)
Unclassified vessels
Unclassified vascular pattern
Definition
Dilated, tortuous, or irregular vessels; patterns other than absent, network, or ISV
Note: Monotype with unclassified vessels → C4/5.
ISV
Intrastructural vascular pattern
Definition
Dilated or tortuous vessels within the mucosal structure
Vienna
Category 4/5 likely (64.3% in series)
Definition
Regular network microvessels
Vienna
Category 3 (all network monotypes were C3 in series)
Note: Regular network → C3 in the Kikuchi series.
Definition
No microvessels visible across a wide area
Vienna
Category 3 likely (33% were C4/5 in series)
Note: Often C3; some C4/5 — confirm with biopsy.
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Decision support only. Follow current guidelines and local protocols. Classification definitions and terminology follow the original publication language.