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CLASSIFICATION
Classification
Lauren classification (gastric adenocarcinoma)
Pathological subtypes of gastric adenocarcinoma: intestinal, diffuse, and mixed (Lauren 1965).
Classification overview
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Lauren
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Intestinal · Intestinal type
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Diffuse · Diffuse type
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Mixed · Mixed type
Lauren
Intestinal
Intestinal type
Histology
Glandular, tubular, or papillary structures; cohesive cells forming glands
Background
Often associated with atrophic gastritis and intestinal metaplasia (Correa pathway)
Prognosis
Varies by stage; distinct molecular profile from diffuse type
Diffuse
Diffuse type
Histology
Poorly cohesive cells; signet-ring cells common; no gland formation
Background
Not preceded by intestinal metaplasia in most cases
Genetics
CDH1 (E-cadherin) loss common in hereditary and sporadic cases
Note: May present as linitis plastica. CDH1 loss is common.
Mixed
Mixed type
Definition
Substantial components of both intestinal and diffuse types in the same tumour
Reporting
Both components should be quantified when possible
Lauren 1965, Original
Reference
Original article
Lauren P. Acta Pathol Microbiol Scand 1965;64:31-49
Related tools
WHO 2019 GI NET grade (G1–G3)
NET G1–G3
CLASSIFICATION
NET G1–G3
→
Kyoto classification risk score (original 0–8)
Atrophy / metaplasia background
SCORE
Kyoto
→
Borrmann classification (advanced gastric cancer)
Advanced gastric macroscopic type
CLASSIFICATION
Borrmann
→
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Decision support only. Follow current guidelines and local protocols. Classification definitions and terminology follow the original publication language.